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Labs and Research Groups

Our current research focuses mainly on hyperthermophiles, which are microorganisms that grow near 100°C, and on the roles of metals in microbial metabolism.  In a basic science project, we are using the archaeon Pyrococcus furiosus, which grows up to 103°C,…

Bt proteins are used to control pest insects on corn, cotton, rice, and other important crops. Many Bt proteins have been discovered and each one is toxic to a narrow group of insects. Increased use of Bt carries the risk that insects will adapt and become resistant…

Avci Lab focuses on mechanisms of immune activation by carbohydrate antigens; design and development of knowledge-based vaccines and therapeutics against pathogens and cancers.


The Analytical Service and Training Laboratory at the CCRC has expertise in structural characterization of glycoconjugates including polysaccharides, glycoproteins  (Glycomics and Glycoprotemics) and glycolipids using mass spectrometry (MALDI-MS, LC…

Our laboratory determined that N-glycosylation of a circulating immunoglobulin was required for receptor binding because long-range contacts within the antibody molecule stabilize key residues to form an interface with the receptor. We believe, based on these results…

The Bioexpression and Fermentation Facility (BFF) was established in 1967 and is one of the largest fermentation pilot plants in the Southeast offering a variety of services from recombinant protein production to monoclonal antibodies.  The BFF consists of the…

Our research focuses on two major areas: 1) functional metabolomics for drug target selection and validation with an emphasis on isoprenoid biosynthesis in the asexual and sexual stages of the malaria parasite, and 2) drug discovery 

The Dailey lab’s research focuses on the enzymes responsible for heme biosynthesis. Current studies involve structure/function investigations of the terminal enzymes of heme biosynthesis and their relationship to the human genetic diseases known as porphyrias,…

The Dalton laboratory is interested in how ‘molecular medicine’ can be used to understand human disease, for the purpose of developing new therapies and cures.


Darvill's research focuses on structurally characterizing the five major noncellulosic carbohydrates of plant primary cell walls homogalacturonan, rhamnogalacturonan I and II, xyloglucan, and glucuronoarabinoxylan. Plant primary cell walls control the rate and…

Our research group is interested in how social psychological and sociocultural phenomena influence student learning, development, and success. Our group primarily studies research experiences, including undergraduate and graduate research, as a context for teaching,…

The Edison lab develops new approaches in metabolomics and natural products research. Our primary research tool is NMR spectroscopy, but we regularly collaborate with experts in mass spectrometry. A major focus is on data integration between NMR, MS, and other…

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Our research concerns the mechanism and consequences of Ty1 retrotransposition in the budding yeast Saccharomyces. The Ty1 life cycle resembles that of…

My laboratory is interested in the molecular and biochemical basis of parasitic diseases.  We are currently studying African trypanosomes which are important protozoan parasites causing human African sleeping sickness and Nagana in cattle.  We have made important…

Short Biography:

Dr. Haltiwanger received his B.S. in Biology (1980) and Ph.D. in Biochemistry (1986) from Duke University. He went on to do postdoctoral work at Johns Hopkins University School of Medicine, and took his first…

We are an inter-disciplinary research group using concepts and techniques from diverse disciplines including biophysics, biochemistry, and bioinformatics to understand how proteins, the molecular machines of life, work. Our current efforts are focused on protein…

Our laboratory is interested in the mechanism of metalloproteins involved in radical generation and radical-catalyzed chemical conversions. All of the enzymes being investigated have significant roles in metabolic processes that are essential…

I investigate how to support college biology instructors as they incorporate reformed teaching strategies into their practice. Reformed teaching strategies are strategies that have been shown to improve student outcomes, such as conceptual understanding, problem…

The work in my laboratory deals with the biosynthesis of heme and it regulation. Heme is an essential cofactor for almost all living organisms and participates in a variety of reactions including the regulation central metabolic processes, oxygen binding and…

Biosynthesis and Biological Function of Pectin

What is Pectin?


The cell wall of plants is a polysaccharide and protein rich macromolecular structure that is essential for plant form and function. It is also the meeting point between the plant and its…

Research in the Moremen lab focuses on the structure, regulation, and localization of enzymes involved in the biosynthesis, recognition, and catabolism of mammalian glycoproteins. Carbohydrate structures on glycoproteins contribute to many biological recognition…

The outer leaflet of the outer membrane of the gram-negative bacterial cell envelope is built of lipopolysaccharide (LPS). The LPS consists of three distinct structural regions; a rather conserved lipid A, a more variable core oligosaccharide (OS), and an even more…

Dr. Orlando conducts research on using mass spectrometry (MS) to answer biological questions. He also is concerned with developing new methodologies to increase the amount of information obtained from MS experiments and to reduce the quantity of material needed for…

The primary focus of the Pierce laboratory centers on understanding the regulation of intercellular recognition and adhesion, particularly those events that involve protein-oligosaccharide interactions. Almost 20 years ago, observations were made that when vertebrate…

Research in the Prestegard laboratory focuses on nuclear magnetic resonance (NMR) methods development and application of those methods to challenging problems involving soluble proteins, membrane proteins, cell-surface carbohydrates, and carbohydrate-protein…

The three dimensional structures of proteins or protein complexes can provide important clues concerning protein function and mechanism of action on a molecular level. The Rose laboratory is interested in using molecular biology coupled with X-ray crystallography and…

Antigenic variation in African trypanosomes


Among the parasites we currently study in the laboratory are African trypanosomes, unicellular eukaryotic protozoa that infect the bloodstream of mammals to cause sleeping sickness in equatorial Africa.…

We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of enzymes involved in the production of isoprenylated proteins. Examples of isoprenylated proteins include the Ras…

The Scott group conducts research in the general areas of biophysical chemistry. Major current research projects include the use of X-ray absorption spectroscopy to study the structure of metals in biological systems, including metal binding sites in metallosensors…

We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide research tools for important biotechnology and biomedical applications


The surfaces of all eukaryotic cells are richly endowed with a diverse array of complex glycoconjugates. Therefore, carbohydrate moieties linked to protein, lipid, and glycosaminoglycan form the interfaces at which cell-cell interactions occur. Consistent with their…

Our research focuses on protein structure and function and protein-protein interactions. We employ an approach combining modern analytical, biophysical and molecular biology techniques, with an emphasis on biomolecular NMR spectroscopy. Our core projects include the…

Application of structural biology tools for the structure-function studies of relevant biological macromolecules, which include RNA polymerases, neurophysins and their hormone complexes, glutathione transferases, glutamine binding protein and complex, aldehyde…

Our primary research interest is to understand the role and the underlying mechanisms of heparan sulfate proteoglycans in angiogenesis, stem cell, hemostasis and leukoctye trafficking/inflammation with a long-term goal to develop novel therapeutics to improve the…

Functional diversity increases as you go from DNA to RNA to Proteins. The concept of one gene encodes one gene product is no longer valid. One of the principle ways that diversity is increased is through post-translational modifications of proteins.


Using a…

Research Areas


OXYGEN SENSING


In addition to its role in driving oxidative metabolism, ambient O2 levels carry information of great interest to cells of both unicellular and multicellular organisms. For example, O2 regulates gene expression and…

My lab studies the relationship between protein structure and function, and specifically how enzyme activity is regulated. To do this, we use a combination of techniques, including X-ray crystallography, transient and steady state kinetic, sedimentation velocity and…

Research in the Woods group examines the relationship between carbohydrate conformation and biological recognition. Areas of particular interest include carbohydrate antigenicity in immunological events, carbohydrate- processing enzymes, and the development of…

Study of Microbial Genome Structure and Application to Pathway & Network Inference:

We are interested in understanding both the micro- and macro-structures of microbial genomes through computational studies and experimental validation, and in…

We study stem cells in skeletal muscle and adipose (fat) tissues and develop therapeutics for muscular dystrophy, muscle atrophy, obesity, and type 2 diabetes. We use transgenic mice and cultured human cells to model human diseases and…

Dr. York's diverse research interests include the development and application of spectroscopic and computational methods for the structural and conformational analysis of complex carbohydrates, the development of bioinformatics tools to study the roles of…

We are using human pluripotent stem cells (human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs)) to differentiate cell types that are affected in diseases of the peripheral nervous system (PNS). Because primary patient PNS cells in…

My lab is using experimental and computational approaches to study genomic and epigenomic changes occurring during cancer initiation and progression, as well as during normal biological processes such as mammalian genome evolution and cell differentiation. The goal…

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