Wells

Our laboratory examines how post-translational modifications (primarily glycosylation) increase functional diversity of proteins.  We are focused on congenital disorders of O-glycosylation that includes forms of X-linked intellectual disability (defects in the O-GlcNAc pathway; OGT-CDG, first biochemically described by our group) and congenital muscular dystrophies (defects in O-Mannosylation). We utilize a combination of genetic, biochemical, cell biology, chemical biology, and analytical biochemistry (with a major focus on mass spectrometry) approaches to address questions in these areas.