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We are studying how nutrients regulate signaling and transcription by O-GlcNAcylation (OGN). OGN is the addition and removal of N-acetylglucosamine from Ser(The) residues of nuclear, cytoplasmic and mitochondrial proteins. The cycling sugar is analogous to phosphorylation and has extensive…
We are using biochemical, cell biological, genetic, and molecular approaches in conjunction with the yeast system to better understand the function of enzymes involved in the production of isoprenylated proteins. Examples of isoprenylated proteins include the Ras family of oncoproteins, Ras-…
We are using human pluripotent stem cells (human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs)) to differentiate cell types that are affected in diseases of the peripheral nervous system (PNS). Because primary patient PNS cells in large numbers are nearly…
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