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Stress is a part of life, even on the cellular level. To survive and adapt to stresses such as nutrient deprivation or temperature shock, cells have to alter gene expression, especially protein translation, and alterations in these responses have been implicated in multiple human pathologies,…
We are using human pluripotent stem cells (human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs)) to differentiate cell types that are affected in diseases of the peripheral nervous system (PNS). Because primary patient PNS cells in large numbers are nearly…
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