The group has a general interest in anaerobic microorganisms, particularly archaea and particularly those growing near and above 100°C, the so-called hyperthermophiles. The archaeon Pyrococcus furiosus and the bacterium Thermotoga maritima are being used as model systems. Projects involve the physiology, metabolism, enzymology, bioinorganic chemistry, and functional and structural genomics of these organisms. For example, the genome of P. furiosus contains approximately 2,200 ORFs, but the functions of much less than half of them are known.