Different Concepts of Molecular Structure

1/10/99


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NOTICE: This material is copyrighted and all right are reserved. (c) 1998, 1999 J. E. Wampler
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Table of Contents

{1} Different Concepts of Molecular Structure

{2} Quantum Mechanical Model

{3} There are some obvious differences...

{4} Compared to the Quantum Mechanical Model...

{5} In spite of these things...

{6} Simplest structure representation describes...

{7} Note: Just knowing where the atoms are may not be enough

{8} Explicit connectivity, can clearify which atoms go together

{9} The absolute positions of the atoms depend on the orientation and position of x,y,z =0,0,0

{10} Indeed, we only need the relative position of each atom to the others.

{11} Bond length, r, and the bond vector, R.

{12} The angle between three atoms (1,2 & 3):

{13} Torsion angle

{14} The cross product...

{15} Such measurements give internal coordinates

{16} The concept of Atom Types

{17} The concept of atom types...

{18} Atom typing is used to ...

{19} Some examples of atom typing...

{20} Some examples of atom typing...

{21} Thus, for a computational program to use PDB structures...

Author: John E. Wampler

Email: wampler@bchiris.bmb.uga.edu

Home Page: http://bmbiris.bmb.uga.edu/BMB8200

References:

Abola, E. E., Bernstein, F. C., Bryant, S. H., Koetzle, T. F., and Weng, J. (1987) Protein Data Bank, in Crystallographic Databases - Information Content, Software Systems, Scientific Applications (F. H. Allen, G. Bergerhoff & R. Sievers, eds.) Data Commission of the International Union of Crystallography, Bonn, pp. 107-132.

Allen, F. H., Bellar, S., Brice, M. D., Cartwright, B. A., doubleday, A., Higgs, H. Hummelink, T., Hummeling-Peters, B. G., Kennard, O., Motherwell, M. D. S., Rodgers, J. R., & Watson, D. G., (1979) The Cambridge Crystallographic Datra Centre: Computer-Based Search, Retrieval, Analysis and Display of Information, Acta Cryst. B35, 2331-2339.

Bernstein, F. C., Koetzle, T. F., Williams, G. J. B., Meyer, E. F. Jr., Brice, M. D., Rodgers, J. R., Kennard, O., Shimanouchi, T., and Tamusi, M. (1977) The Protein Data Bank: A Computer-based Archival File for Macromolecular Structures, J. Mol. Biol. 112, 535-542.

Creighton, T. E. (1993) "Proteins Structures and Molecular Properties," W. H. Freeman and Company, New York. Chapter 6.

Leach, A. R. (1996) "Molecular Modeling Principles and Applications," Addison Wesley Longman Limited, Essex, England. Chapter 1.