Publications:

Chapters in books and reviews:

  1. Moremen, K.W. and Molinari, M.(2006) N -linked glycan recognition and processing: the molecular basis of ER quality control Curr. Opinion Structural Biol. in press.
  2. Lee, J.-K. Baum, L.G., Moremen, K. , Pierce, M. (2004) The X-lectins: A new family with homology to the Xenopus laevis oocyte lectin XL-35 Glycoconj. J. 21 , 443-450.
  3. Moremen, K.W. (2002) Golgi a-Mannosidase II deficiency in vertebrate systems: implications for Asparagine-linked oligosaccharide processing in mammals Biochim. Biophys. Acta, 1573, 225-235.
  4. Moremen, K. W. (2002) a-Mannosidase II in Handbook of Glycosyltransferases and Related Genes , (N. Taniguchi and M. Fukuda, eds.) Springer-Verlag, Tokyo, pp. 600-606
  5. Moremen, K. W. (2000) a-Mannosidases in Asparagine-linked Oligosaccharide Processing and Catabolism. in Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook , Vol. II, Part 1 (B. Ernst, G. Hart, and P. Sinay, eds.) Wiley and Sons Publishers, 81-117.
  6. Moremen, K. W., Trimble, R. B., Herscovics, A. (1994) Glycosidases of the Asparagine-linked Oligosaccharide Processing Pathway. Glycobiology   4 , 113-125.
  7. Trimble, R. B., Moremen, K.W. , and Herscovics, A. (1994) Mannosidases of the Golgi Apparatus. in Guidebook to the Secretory Pathway   (J. A. Rothblatt, T. Stevens, and P. Novick eds.) Sambrook and Tooze Scientific Publishers. pp. 185-188.
  8. Trimble, R. B., Moremen, K.W. , and Herscovics, A. (1994) N-glycan processing in the endoplasmic reticulum in Guidebook to the Secretory Pathway   (J. A. Rothblatt, T. Stevens, and P. Novick eds.) Sambrook and Tooze Scientific Publishers. pp. 100-104.
  9. Moremen, K. W. and Touster, O. (1987) Mannosidases in Mammalian Glycoprotein Processing. in Protein Transfer and Organelle Biogenesis   (R.C. Das and P.W. Robbins eds.) Academic Press,   pp. 209-240.

Journal Articles:

  1. Akama, T.O., Nakagawa, H., Wong, N.-K. Sutton-Smith, M., Dell, A., Nakayama, J., Nishimura, S., Pai, A., Moremen, K.W., Marth, J.D., and Fukuda, M.N.   (2006) Essential and mutually compensatory roles of a-mannosidase II and a-mannosidase IIx in N -glycan processing in vivo in mice. Proc. Natl. Acad. Sci. U.S.A. 103, 8983-8988
  2. Mast, S.W. and Moremen, K.W. (2006) Family 47 a -Mannosidases in N-glycan processing Meth. Enzymol. in press.
  3. Herring, K.W., Karaveg, K., Moremen, K.W. , and Pearson, W.H. (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum a-mannosidase I J. Org. Chem. 70 , 9892-9904.
  4. Park, C., Meng, L. Stanton, L.H., Collins, R.E., Mast, S. W., Yi, X., Strachan, H., and Moremen, K.W. (2005) Characterization of a human core-specific lysosomal a1,6-mannosidase involved in N-glycan catabolism, J. Biol Chem. 280 , 37204-37216
  5. Karaveg, K. and Moremen, K.W. (2005) Energetics of substrate binding and catalysis by Class 1 (glycosylhydrolase family 47) a-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J. Biol Chem. 280 , 29837-29848
  6. Siriwardena, A., Strachan, H., El-Daher, S., Way, G., Winchester, B., Glushka. J., Moremen, K. , Boons, G.J. (2005) Potent and Selective Inhibition of Class II a-D-Mannosidase Activity by a Bicyclic Sulfonium Salt Chembiochem . 6 , 845-848.
  7. Karaveg, K., Siriwardena, A., Tempel, W., Liu, Z.-J., Glushka, J., Wang, B.-C., and Moremen, K.W. (2005) Mechanism of Class 1 (glycosylhydrolase family 47) a -mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J. Biol Chem. 280 , 16197-16207
  8. Mast, S.W., Diekman, K., Karaveg, K., Davis, A., Sifers, R.N. , and Moremen, K.W. (2004) Human EDEM2, a novel homolog of family 47 glycosidases, is involved in the ER-associated degradation of glycoproteins. Glycobiology, 15 , 421-436
  9. Li, B., Kawatkar, S.P., George, S., Strachan, H., Woods, R.J., Siriwardena, A., Moremen, K.W. , Boons, G.J. (2004) Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chembiochem. 5 , 1220-7
  10. Tempel, W., Karaveg, K., Lui, Z. –J., Rose, J., Wang, B.-C. and Moremen, K.W. (2004) Structure of mouse Golgi a-mannosidase IA reveals the molecular basis for substrate specificity among Class I (family 47 glycosyl hydrolase) a1,2-mannosidases.J. Biol. Chem., 279, 29774-29786
  11. Wu, Y., Moremen, K.W., Sifers, R.N. (2003) Elucidation of the molecular logic that preferentially targets misfolded alpha1-antitrypsin for intracellular degradation. Submitted.
  12. Cabral, C.M., Liu, Y., Moremen, K.W., and Sifers, R.N. (2002) Organizational diversity among distinct glycoprotein ER-associated degradation programs Mol. Biol. Cell 13, 2639-2650
  13. Akama, T.O., Nakagawa, H., Sugihara, K., Narisawa, S., Ohyama, C., Nishimura, S., O’Brien, D.A., Moremen, K.W., Millan, J.L., and Fukuda, M.N. (2002) Germ cell survival through carbohydrate-mediated interaction with Sertoli cells Science 295, 124-127.
  14. Rivera-Marrero, C.A., Ritzenthaler, J.D., Roman, J., Moremen, K.W. (2001) Molecular cloning and expression of an a-mannosidase gene in Mycobacterium tuberculosis. Microb Pathog 30: 9-18
  15. Kawar, Z., Karaveg, K., Moremen, K.W., and Jarvis, D.L., (2001) Insect cells encode a Class II a-mannosidase with unique properties. J. Biol. Chem. 276 16335-16340..
  16. Oh-eda, M., Nakagawa, H., Akayama, T.O., Lowitz, K., Misago, M., Moremen, K.W., and Fukuda, M.N. (2001) Overexpression of the Golgi-localized enzyme a-mannosidase IIx in Chinese hamster ovary cells results in the conversion of hexamannosyl-N-acetylchitobiose to tetramannoseyl-N-acetylchitobiose in the N-glycan processing pathway, Eur. J. Biochem. 268, 1280-1288.
  17. Lee, J.-K., Schnee, J., Pang,M., Wolfert, M, Baumn, L.G., Moremen, K.W., Pierce, M. (2001) Human homologs of the Xenopus oocyte cortical granule lectin XL35. Glycobiology 11, 65-73.
  18. Vallee, F., Karaveg, K., Herscovics, A., Moremen, K.W., Howell, P.L. (2000) Structural basis for catalysis and inhibition of N-glycan processing Class 1 a1,2-mannosidases. J. Biol. Chem., 275, 41287-41298
  19. Gonzalez, D. S., Karaveg, K., Vandersall-Nairn, A. S., Lal, A., and Moremen, K. W. (1999) Identification, expression, and characterization of a cDNA encoding human ER mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J. Biol. Chem., 274, 21375-21386.
  20. Igdoural, S.A., Herscovics, A., Lal, A., Moremen, K.W., Morales, C.R., and Hermo, L. (1999) a-Mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymus. E. Jour. Cell Biology 78, 441-452.
  21. Gonzalez, D.S., Kagawa, Y., and Moremen, K.W. (1999) Isolation and Characterization of the Gene Encoding the Mouse Broad Specificity Lysosomal a-Mannosidase. Biochim. Biophys. Acta 1445, 177-183.
  22. Di Virgilio, S, Glushka, J., Moremen, K.W., and Pierce, M. (1999) Enzymatic synthesis of natural and 13C enriched linear poly-N-Acetyllactosamines as ligands for galectin-1. Glycobiology 9, 353-364.
  23. Valee, F., Lal, A., Moremen, K.W., and Howell, P.L. (1999) Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a Class I a-mannosidase involved in Asn-linked oligosaccharide maturation. Acta Crystallog. D55, 571-573
  24. Vandersall-Nairn, A., O'Brien, K., Merkle, R. K, Oeltmann, T. N., and Moremen, K.W. (1998) Cloning and expression of the lysosomal acid a-mannosidase of Trypanosoma cruzi. Glycobiology, 8, 1183-1194
  25. Lal, A., Pang, P., Kalelkar, S., Romero, P.A., Herscovics, A., and Moremen, K.W. (1998) Substrate specificities of recombinant murine Golgi a1,2-mannosidases IA and IB and comparison with endoplasmic reticulum and Golgi processing a1,2-mannosidases Glycobiology 8, 981-995
  26. Howard, S., Braun, C., McCarter, J., Moremen, K.W., Liao, Y.-F., and Withers, S.G. (1997) Human lysosomal and jack bean a-mannosidases are retaining glycosidases. Biochem. Biophys. Res. Commun., 238, 896-898
  27. Chui, D., Oh-eda, M., Liao, Y.-F., Panneerselvam, K., Lal, A., Marek, K.W., Freeze, H.H., Moremen, K.W., Fukuda, M.N., and Marth, J.D. (1997) Alpha-mannosidase-II deficiency results in Dyserythropoietic Anemia and unveils an alternate pathway in complex asparagine-linked oligosaccharide biosynthesis, Cell, 90, 157-167.
  28. Merkle, R.K., Zhang, Y., Ruest, P.J., Lal, A., Liao, Y.-F., and Moremen, K.W. (1997) Cloning, Expression, Purification, and Characterization of the Murine Lysosomal Acid a-mannosidase. Biochim. Biophys. Acta, 1336, 132-146.
  29. Jarvis, D.L., Bohlmeyer, D.A., Liao, Y.-F., Lomax, K.K., Merkle, R.K., and Moremen, K.W. (1996) Isolation and characterization of a class II a-mannosidase cDNA from lepidopteran insect cells, Glycobiology, 7, 113-127
  30. Lee, J. K., Buckhaults, P., Wilkes, C., Teilhet, M., King, M.L., Moremen, K.W., and Pierce, M. (1996) Cloning and expression of a Xenopus laevis oocyte lectin and characterization of its mRNA levels during early development (1996) Glycobiology, 7, 367-372.
  31. Liao, Y.-F., Lal, A., and Moremen, K.W. (1996) Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid a-mannosidase J. Biol. Chem. 271, 28348-28358
  32. Prieto, P., Mukerji, P., Kelder, B., Erney, R., Gonzales, D., Yun, J., Cummings, R., Smith, D. F., Moremen, K. W., Nardelli, C., Pierce, M., and Kopchick, J. J. (1995) Remodeling of mouse milk glycoconjugates by transgenic expression of a human glycosyltransferase. J. Biol. Chem. 270, 29515-29519
  33. Misago, M., Liao, Y.-F., Kudo, S., Mattei, M.- G., Moremen, K. W., and Fukuda, M. N. (1995) Molecular cloning and expression of cDNAs encoding human a-mannosidase II and a novel a-mannosidase IIx isozyme Proc. Natl. Acad. Sci. U.S.A. 92, 11766-11770.
  34. Lal, A., Schutzbach, J. S., Forsee, W. T., Neame, P., and Moremen, K.W. (1994) Isolation and expression of a murine and rabbit a1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides. J. Biol. Chem. 269, 9872-9881.
  35. Herscovics, A., Schneikert, J., Athanassiadis, A., and Moremen, K.W. (1994) Isolation of a mouse Golgi mannosidase cDNA, member of a gene family conserved from yeast to mammals. J. Biol. Chem. 269, 9864-9871.
  36. Oeltman, T., Carter, C., Merkle, R. and Moremen, K. W. (1994) The a-mannosidase of Trypanosoma cruzi: structure and function. Brazilian J. Med. Biol. Res. 27, 483-488.
  37. Sasisekharan, R., Bulmer, M., Moremen, K.W., Cooney, C. L., Langer, R. (1993) Cloning and expression of Heparinase I Gene from Flavobacterium heparinum. Proc. Natl. Acad. Sci. U.S.A., 90, 3660-3664.
  38. Velasco, A., Moremen, K.W., Hendricks, L. Tulsiani, D. R. P., Touster, O., and Farquhar, M. G., (1993) Cell-type dependent variations in the subcellular distribution of a-mannosidase IA and II. J. Cell Biol. 122, 39-51.
  39. Zuber, C., Roth, J., Mistelli, T., Nakano, A., Moremen, K.W. (1991) DS 28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses the key phenotypic changes associated with Brefeldin A treatment. Proc. Natl. Acad. Sci.U.S.A., 88, 9818-9822.
  40. Moremen, K.W. and Robbins, P.W. (1991) Isolation, characterization, and expression of cDNA encoding murine a-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans J. Cell Biol. 115, 1521-1534.
  41. Moremen, K.W., Robbins, P.W., and Touster, O. (1991) Novel purification of the catalytic domain of Golgi mannosidase II: characterization and comparison with the intact enzyme. J. Biol. Chem. 266, 16876-16885.
  42. Bischoff, J., Moremen, K.W., and Lodish, H. (1990) Isolation, characterization, and expression of a cDNA encoding the rat liver endoplasmic reticulum a-mannosidase. J. Biol. Chem. 265, 17110-17117.
  43. Fukuda, M. N., Masri, K.A., Dell, A., Luzzato,L., and Moremen, K.W. (1990) Incomplete synthesis of N-glycans in congenital dyserythropoetic anemia II (HEMPAS) caused by a gene defect encoding a-mannosidase II. Proc. Natl. Acad. Sci. U.S.A. 87, 7443-7447.
  44. Moremen, K.W. (1989) Isolation of a rat liver Golgi mannosidase II clone by mixed oligonucleotide-primed amplification of cDNA. Proc. Natl. Acad. Sci. U.S.A. 86, 5276-5280.
  45. Moremen, K.W. and Touster, O. (1986) Topology of mannosidase II in rat liver Golgi membranes and release of the catalytic domain by selective proteolysis. J. Biol. Chem. 261, 10945-10951.
  46. Moremen, K.W. and Touster, O. (1985) Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells. J. Biol. Chem. 260, 6654-6662.

Manuscripts in preparation:

Abstracts (partial list):
  1. Park, C., Meng, L., Stanton, L., Collins, R., Strachan, H., and Moremen, K.W. (2005) Characterization of a human core-specific lysosomal a1,6-mannosidase involved in glycan catabolism. Glycobiology,
  2. Nairn, A.V., York, W.S., Gilmartin, T.J., Head, S.R., Nash, R.J., Dalton, S., North, S.J., Haslam, S.M., Dell, A., and Moremen, K.W. (2005) Development of a high-throughput transcript analysis of glycan-related genes and a cross-platform comparison with microarray expression analysis and correlation with relative quanitation of glycan mass spectral analysis. Glycobiology,
  3. Karaveg, K., Siriwardena, A., Tempel, W., Liu, Z.-J., Glushka, J., Wang, B.-C., and Moremen, K.W. (2005) Mechanism and energetics of substrate binding and catalysis for Class 1 (glycosylhydrolase family 47) a -mannosidases involved in N-glycan processing and quality control. Glycoconjugate J., 22, 298.
  4. Dalton, S., Moremen, K. , Nairn, A., Alvarez-Manilla, G., Merrill, A., Lee, J.-K., Lee, I., Abbott, K., Matthews, R., Pierce, M. (2004) Glycomic analysis of mouse embryonic stem cell differentiation. Glycobiology, 14, 1019.
  5. Park, C., Stanton, L., Collins, R., and Moremen, K.W. (2004) Characterization of a novel human core-specific lysosomal a 1,6-mannosidase involved in glycan catabolism. Glycobiology, 14, 10
  6. Karaveg, K., Siriwardena, A., Tempel, W., Liu, Z.-J., Wang, B.-C., and Moremen, K.W. (2004) Mechanism of substrate binding and catalysis for Class 1 (glycosylhydrolase family 47) a -mannosidases. Glycobiology, 14, 1030.
  7. Singh, H., Strachan, H., Fukuda, M.N., and Moremen, K.W. (2004) Substrate specificity of Golgi a-mannosidase IIx indicates a functional redundancy with Golgi a-mannosidase II in animal tissues. Glycobiology, 14, 1030.
  8. Mast, S.W., Diekman, K., Karaveg, K., Davis, A., Sifers, R.N. , and Moremen, K.W. (2004) Human EDEM2, a novel homolog of family 47 glycosidases, is involved in the ER-associated degradation of glycoproteins. Glycobiology, 14, 1037.
  9. Akama, T.O., Nakayama, J., Nakagawa, H., Wong, N., Sutton-Smith, M., Nishimura, S., Moremen, K.W., Dell, A., Marth, J., Fukuda, M.N. (2003) Enzymatic activity of a-mannosidase IIx in N-glycan biosynthesis. Glycobiology 14, 1039.
  10. Nairn. A. V. and Moremen, K.W. (2004) Development of a quantitative real-time PCR method for analyzing transcript abundance of glycan-related genes in mouse tissues and embryonic stem cells. Glycobiology, 14, 1049
  11. Akama, T.O., Nakayama, J., Nakagawa, H., Wong, N., Sutton-Smith, M., Nishimura, S., Moremen, K.W., Dell, A., Marth, J., Fukuda, M.N. (2003) a-Mannosidase IIx is responsible for as alternate N-glycan processing pathway to a-mannosidase II in vivo. Glycobiology 13, 827.
  12. George, S., Li, B., Strachan, H., Ayres, R., Collins, R., Siriwardena, A., Moremen, K.W., and Boons, G.-J. (2002) Development of selective inhibitors of processing and catabolic Class 2 (family 38 glycosyl hydrolase) a-mannosidases: synthesis and evaluation of mannostatin derivatives. Glycobiology, 12, 668
  13. Stanton, C., magnum, J., Strachan, H., Ayres, R., Collins, R., Boons, G.-J., Moremen, K.W., and Siriwardena, A. (2002) Design and synthesis of sulfonium salts and azasugar analogs of swainsonins as selective inhibitors of processing and catabolic Class 2 (family 38 glycosyl hydrolase) a-mannosidases. Glycobiology, 12, 668
  14. Tempel, W., Karaveg, K., Lui, Z. –J., Rose, J., Moremen, K.W., and Wang, B.-C. (2002) Structure of mouse Golgi mannosidase IA reveals the molecular basis for substrate specificity among Class I (family 47 glycosyl hydrolase) a1,2-mannosidases. Glycobiology, 12, 697.
  15. Mast, S., Aebi, M., and Moremen, K. W. (2001) Role of selected domains and conserved residues in the function of HTM1p/Mnl1p in ER associated degradation of glycoproteins in yeast. Glycobiology 11, 909.
  16. Vandersall-Nairn, A., R. K, Oeltmann, T. N., and Moremen, K.W. (2001) Studies on the biosynthesis and targeting of the acid a-mannosidase from Trypanosoma cruzi in mammalian cells. Glycobiology 11, 899
  17. Lee, J.-K., Tracey, A., Kohatsu, Baum, L., Moremen, K.W., and Pierce, M. (2001) Characterization of the Xenopus oocyte cortical granule lectin and its human homologs. Glycobiology 11, 885.
  18. Pierce, M., Schnee, J., Pang, M., Wolfert, M., Baum, L.G., Lee, J.-K., and Moremen, K. W. (2000) Human and mouse homologs of the Xenopus oocyte cortical granule lectin XL-35 Glycobiology 10, 1085.
  19. Moremen, K. W. Vallee, F., Karaveg, K., Mast, S., Herscovics, A., and Howell, P. l. (2000) Structure and function of Class 1 a-mannosidases in glycoprotein maturation and quality control Glycobiology 10, 1079
  20. Valee, F, Yip, P., Lipari, F., Sleno, B., Romero, P., Karaveg, K., Moremen, K., Herscovics, A., Howell, P.L. (2000) Structure and function of Class I a1,2-mannosidase involved in N-glycan processing and ER quality control Glycobiology 10, 1141.
  21. Fukuda, M.N., OhedaM., Akama, T., Nakagawa, H., Misago, M., and Moremen, K.W. (1999) Characterization and in vivo role of a-mannosidase Iix, an enzyme encoded by a gene similar to the Golgi mannosidase II. Glycoconj. J. 16, S6.
  22. Moremen K.W., Gonzalez, D.S., Karaveg, K., Vandersall-Nairn, A.S., and Lal, A. (1999) Identification, expression, and characterization of a cDNA encoding human ER mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. Glyconj. J. 16, S124.
  23. Moremen, K.W., Gonzalez, D.S., Karaveg, K., Vandersall-Nairn, A. S., and Lal, A. (1999) Identification, expression, and characterization of a cDNA encoding human ER mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. Glycobiology, 9, 1128.
  24. Lal, A., Pang, P., Kalelkar, S., Romero, P., Herscovics, A., and Moremen, K.W. (1997) Substrates specificity of recombinant alpha1,2-mannosidase IA and IB. Glycoconjugate J., 14, S123.
  25. Liao, Y.F. and Moremen, K.W. (1997) Characterization of genetic defects in human alpha-mannosidosis patients. Glycoconjugate J., 14, S47.
  26. Oh-eda, M., Misago, M., Moremen, K.W., Fukuda, M., and Fukuda, M.N. (1997) Characterization of human alpha-mannosidase IIx and its potential involvement in an alternative pathway for complex N-glycan biosynthesis. Glycoconjugate J., 14, S29.
  27. Lee, J.K., Moremen, K.W., and Pierce, M (1997) Discovery of a new superfamily of animal lectins. Glycoconjugate J., 14, S63.
  28. Vandersall-Nairn, A., R. K, Oeltmann, T. N., and Moremen, K.W. (1997) Purification and post-translational processing of recombinant acid a-mannosidase of Trypanosoma cruzi. Glycobiology, 7, 1044
  29. Zhang, Y., Merkle, R.K., Ruest, P. j., Lal, A., Liao, Y.-F., and Moremen, K.W. (1997) Expression, purification, and characterization of the murine lysosomal a-mannosidase. Glycobiology, 7, 1038
  30. Gonzalez, D. S., Kagawa, Y., and Moremen, K.W.(1996) Genomic Organization and Chromosomal Mapping of the Human and Mouse Lysosomal a-Mannosidases. Glycobiology, 6, 76
  31. Vandersall-Nairn, A., O'Brien, K., Merkle, R. K, Oeltmann, T. N., and Moremen, K.W. (1996) Cloning and Expression of the Acid a-Mannosidase of Trypanosoma cruzi. Glycobiology, 6, 769
  32. Liao, Y.-F., Lal, A., and Moremen, K.W. (1996) Expression and Characterization of the Human Lysosomal a-Mannosidase cDNA and Characterization of the Defect in Human a-Mannosidosis, Glycobiology, 6, 728
  33. Lal, A., Herscovics, A., and Moremen, K.W. (1996) Biochemical Characterization and Substrate Specificity of Murine Class I Mannosidases, Glycobiology, 6, 729
  34. Fukuda, M.N., Masago, M., and Moremen, K.W. (1996) Defect of the Golgi a-Mannosidase II in HEMPAS disease. International Symposium on Molecular and Cell Biology of Glycocongugate Expression.
  35. Chui, D., Ellies, L.G., Moremen, K.W., Fukuda, M.N., and Marth, J.D. (1996) Analyses of Mice Lacking a-Mannosidase II Gene function: a Model of HEMPAS/CDA type II Disease. International Symposium on Molecular and Cell Biology of Glycocongugate Expression.
  36. Moremen, K.W.,Lal, A., Liao, Y.-F., Gonzalez, D., Kagawa, Y., Merkle, R.K., Y. Zhang, Y., Vandersall, A., Ruest, P.J., Oeltmann, T., and Herscovics, A. (1996) Isolation and Characterization of Mammalian Processing and Catabolic a-Mannosidases. International Symposium on Molecular and Cell Biology of Glycocongugate Expression.
  37. Lee, J.-L., Moremen, K.W., and Pierce, M. (1996) Discovery of a new family of C-type vertebrate lectins International Symposium on Molecular and Cell Biology of Glycocongugate Expression.
  38. Lee, J.-L., Moremen, K.W., and Pierce, M. (1996) Discovery of a new family of C-type vertebrate lectins FASEB J., 10, A1226.
  39. Jarvis, D.L., Merkle, R.K., Bohlmeyer, D.A., Lomax, K.K., Liao, Y.-F., and Moremen, K.W. (1995) Using Molecular Genetics to Study the N-Glycosylation Pathway in Lepidopteran insect cells. Fourteenth Annual Meeting of the American Society for Virology.
  40. Oeltmann, T., Carter, C., Merkle, R., and Moremen, K.W. (1994) The a-mannosidase of Trypanosoma cruzi: Structure and function. Glycobiology 4, 734.
  41. Moremen, K.W., Lal, A., Liao, Y-F. and Merkle, R. K. (1994) Mannosidase multi-gene families in glycoprotein biosynthesis and catabolism. Glycobiology 4, 734.
  42. Merkle, R. K. and Moremen, K.W. (1994) cDNA cloning of a murine lysosomal a-mannosidase. Glycobiology 4, 734.
  43. Liao, Y-F., Ponder, C. and Moremen, K.W. (1994) Isolation of human a-mannosidase II cDNA and characterization of the HEMPAS defect in a-mannosidase II. Glycobiology 4, 733.
  44. Lal, A., Schutzbach, J. S., Forsee, W. T., Neame, P. J. and Moremen, K.W. (1994) Isolation, expression and characterization of a murine a1, 2-mannosidase. Glycobiology 4, 733.
  45. Jarvis, D. L., Merkle, R. K., Bohlmeyer, D. A., Liao, Y-F. and Moremen, K.W. (1994) Cloning and characterization of an insect (Sf9) homolog of the mammalian processing enzyme, a-mannosidase II. Glycobiology 4, 733.
  46. Rivera-Marrero, C. A., Tonon, S. A., Cummings, R. D., and Moremen, K.W. (1994) Studies on the structure and function of the stem domain of the murine a1,3-Galactosytltransferase. J. Cell. Biochem. 18D, 272.
  47. Moremen, K.W., Lal, A., Schutzbach, J. S., Forsee, W. T., Neame, P. J., Schneikert, J., Athanassiadis, and Herscovics, A. (1994) Molecular biology of processing mannosidases. J. Cell. Biochem. 18D, 260.
  48. Merkle, R. K, and Moremen, K.W. (1993) Cloning of a murine homolog of the Dictyostelium disciodeum lysosomal a-mannosidase. Glycoconjugate J. 10, 240.
  49. Herscovics, A., Schneikert, J., Athanassiadis, A., Moremen, K.W., and Robbins, P. W. (1993) Isolation of a mouse cDNA encoding a processing mannosidase. Glycoconjugate J. 10, 240.
  50. Velasco, A., Moremen, K. W., Touster, O., Hendricks, L., and Farquhar, M. G. (1991) Variable immunolocalization of a-mannosidases IA and II in the Golgi complex of different cell types. J. Cell Biol. 115, 410a.
  51. Zuber, C., Roth, J., Mistelli, T., Nakano, A., and Moremen, K.W. (1991) A temperature sensitive mutant of Chinese Hamster Ovary cells expresses key phenotypic changes assocoated with Brefeldin A treatment. J. Cell Biol. 115, 64a.
  52. Zuber, C., Nakano, A., Moremen, K.W. and Roth, J. (1991) Temperature-sensitive mutant of Chinese hamster ovary cells with a reversible block in protein secretion, Golgi apparatus disassembly and redistribution of the Golgi apparatus components into the Endoplasmic reticulum. Glycoconjugate J. 8, 136.
  53. Herscovics, A., Moremen, K.W., and Robbins, P.W. (1991) Demonstration of a novel a-mannosidase gene in mammalian cells. Glycoconjugate J., 8, 149.
  54. Kubushiro, K., Moremen, K.W., and Fukuda, M.N. (1991) HEMPAS disease: Mutation in a-mannosidase II gene. Glycoconjugate J., 8, 149.
  55. Moremen, K.W., Schutzbach, J.S., Forsee, W.T., Neame, P., Bischoff, J., and Lodish, H.F. (1990) Molecular biology of processing a-mannosidases. Glycoconjugate J. 7, 401.
  56. Fukuda, M. N., Masri, K.A., Dell, A., Luzzato,L., and Moremen, K.W. (1990) Defective N-glycan synthesis of erythrocyte membrane glycoproteins caused by low expression of a-mannosidase II in a HEMPAS patient. FASEB J. 4, A 1980.
  57. Moremen, K.W. and Robbins, P.W. (1989) Cloning and characterization of murine Golgi mannosidase II. J. Cell Biol. 109, 225a.
  58. Moremen, K.W. and Robbins, P.W. (1988) Molecular approaches for glycoprotein cloning. Glycoconjugate J. 5, 365.
  59. Moremen, K.W. and Touster, O. (1986) A Novel Purification of the Catalytic Domain of Golgi Mannosidase II : Comparison with the Intact Enzyme. Fed. Proc.,45, 1680.
  60. Moremen, K.W. and Touster, O. (1985) Topology of Mannosidase II in Rat Liver Golgi Membranes and Release by Selective Proteolysis. Fed. Proc. 44, 478.
  61. Moremen, K.W. and Touster, O. (1984) Biosynthesis of Golgi Mannosidase II in 3T3 and HeLa Cells. Fed. Proc. 43, 1715.

COMPLEX CARBOHYDRATE RESEARCH CENTER | 220 RIVERBEND ROAD
THE UNIVERSITY OF GEORGIA | ATHENS | GEORGIA 30602 | USA
1-706-542-4401 | FAX: 1-706-542-4412

DEPARTMENT OF BIOCHEMISTRY & MOLECULAR BIOLOGY | B122 LIFE SCIENCES BUILDING
THE UNIVERSITY OF GEORGIA | ATHENS | GEORGIA 30602 | USA
1-706-542-1334 | FAX: 1-706-542-1738