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Distinguished Research Professor
Associate Vice President for Research
B. S., 1975, University of Illinois at Urbana-Champaign
Ph.D., 1980, California Institute of Technology
Office: 604A Boyd GSRC
Contact Phone Number: 542-3739
Lab: 674 Chemistry
Lab Phone: 542-2270
E-mail: scott@chem.uga.edu Additional Information / Lab Page |
Research Interests
The Scott group conducts research in the general areas of biophysical chemistry. Major current research projects include the use of X-ray absorption spectroscopy to study the structure of metals in biological systems, including metal binding sites in metallosensors and metalloregulators, as well as study of the metalloproteome. We also have an interest in selenobiology and the use of selenium substitution for sulfur in the study of substrate and coenzyme interactions with metal sites. Our other significant interest is in the field of archaeal transcription initiation and regulation. In addition to using biophysical and structural biology tools to define the molecular topography of the transcription initiation complex, we employ genomics and proteomics tools to discover new regulatory transcription factors in the hyperthermophilic marine archaeon Pyrococcus furiosus.
Selected Recent Publications
- "Rational Design of a Mononuclear Metal Site into the Archaeal Rieske-type Protein Scaffold" Iwasaki, T.; Kounosu, A.; Tao, Y.; Li, Z.; Shokes, J. E.; Cosper, N. J.; Imai, T.; Urushiyama, A.; Scott, R. A. J. Biol. Chem. 2005, 280, 9129-9134.
- "Bottlenecks and Roadblocks in High-Throughput XAS for Structural Genomics" Scott, R. A.; Shokes, J. E.; Cosper, N. J.; Jenney, F. E.; Adams, M. W. W. J. Synchrotron Radiation 2005, 12, 19-22. [invited article]
- "Direct Interaction of Coenzyme M with the Active-site Fe-S Cluster of Heterodisulfide Reductase" Shokes, J. E.; Duin, E. C.; Bauer, C.; Jaun, B.; Hedderich, R.; Koch, J.; Scott, R. A. FEBS Lett. 2005, 579, 1741-1744.
- "Structural Basis for Metal Binding Specificity: The N-Terminal Cadmium Binding Domain of the P1-Type ATPase CadA" Banci, L.; Bertini, I.; Ciofi-Baffoni, S.; Su, X.-C.; Miras, R.; Bal, N.; Mintz, E.; Catty, P.; Shokes, J. E.; Scott, R. A., J. Mol. Biol. 2006, 356, 638-650.
- "Modulating Amyloid Self-assembly and Fibril Morphology with Zn2+" Dong, J.; Shokes, J. E.; Scott, R. A.; Lynn, D. G. J. Am. Chem. Soc. 2006, 128, 3540-3542.
- "EXAFS structure refinement supplemented by computational chemistry" Hsiao, Y.-W.; Tao, Y.; Shokes, J. E.; Scott, R. A.; Ryde, U. Phys. Rev. B 2006, 74, 214101-1 to -17.
For copies, see http://rscott.myweb.uga.edu/publications.html
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