8120

Instructors:
Michael Terns (A326B Life Sciences, mterns@bmb.uga.edu, 2-1896). Appointment only.
Walter Schmidt (A414B Life Sciences, wschmidt@bmb.uga.edu, 3-8241). Call for appointment or office hours: 8:30-9:30 AM.

Focus: Post-transcriptional and post-translational regulation of gene expression. This will primarily be a literature-driven course. The instructors will give general lectures to introduce the topics. These topics will then be explored in great depth by student presentations/class discussions of selected manuscripts related to the topic.

Date	Topics	Presenter	Papers	Instructor
8/22	Course Overview Introduction - Topic A	Dr. Schmidt Dr. Terns	- -	- -
8/29	Brain-Specific Non-Coding RNAs	Caryn Hale Eladio Abreu	Vitali et al., 2005 Kishore and Stamm, 2006	Terns
9/5	MicroRNAs and Cancer	- Ling Zhao	Johnson et al., 2005 Voorhoeve et al., 2006	Terns
9/12	MicroRNAs and Animal Development	Jerrod Bryson Sarah Lackay	Giraldez et al., 2006 Wu et al., 2006	Terns
9/19	MicroRNAs and Cell Fate Determination	Taylor Barbosa Sarah Lackay	Naguibneva et al., 2006 Schratt et al., 2006	Terns
9/26	Novel Small Regulatory RNAs	Jennifer Pfeiffer Han Zhang	Aravin et al., 2006 Vagin et al., 2006	Terns
10/3	P-Bodies	Mark Stead Benjamin Parrot	Pillai et al., 2005 Liu et al., 2005	Terns
10/10	Transcriptional Gene Silencing in Plants Introduction - Topic B	Han Zhang Dr. Schmidt	Li et al., 2006 OR Pontes et al., 2006 -	Terns Schmidt
10/17	FTase and Rce1 - Dev. and Cell biology	Benjamin Parrot Caryn Hale	Mijimolle et al., 2005 Michaelson et al., 2005	Schmidt
10/24	ICMT - cancer biology	Taylor Barbosa Taylor Barbosa	Bergo et al, 2004 Winter-Vann et al, 2005	Schmidt
10/31	Ras signaling platforms	Eladio Abreu Jerrod Bryson	Onken et al, 2006 Bivona et al, 2006	Schmidt
11/7	Palmitoylation and neurobiology	Jerrod Bryson Sarah Lackay*	Hayashi et al, 2005 Yanai et al, 2006	Schmidt
11/14	Palmitoylation and infectious disease	Jennifer Pfeiffer Ling Zhao	Thorp et al, 2005 Yu et al, 2006	Schmidt
11/21	Palmitoylation in plants and yeast	Han Zhang Mark Stead	Hemsley et al, 2005 Subramaninan et al, 2006	Schmidt
11/28	Palmitoylation and Ras	- Ling Zhao	Rocks et al, 2005 Goodwin et al, 2005	Schmidt

Presentations: A 500-750 word synopsis of the presented paper must be turned in at the beginning of the discussion class by the discussion leaders as well as 5 questions that will be used to stimulate discussion of the paper. Presenters should be prepared to present the assigned literature in an effective manner and be knowledgeable of background material. All students should be prepared to discuss the material in a detailed manner to (e.g., to explain hypotheses, interpret figures, explain advantages/drawbacks of experimental approaches, suggest future directions, etc.). See: Presentation Guidelines.

Advanced Topics in Gene Expression BCMB/GENE 8120 (#89-369), Fall 2006 Tue 3:35-5:30 PM, Davison Life Sciences Complex, Room C130

Advanced Topics in
Gene Expression
BCMB/GENE 8120 (#89-369), Fall 2006
Tue 3:35-5:30 PM, Davison Life Sciences Complex, Room C130